26

Silvia Heiss

  • Academic degree:Dr. tech. nat.,  Mag., BSc.
  • Date of birth: November 11th, 1985
  • Place of birth: Rum i. T.
  • Citizenship: Austria

Mail: silviaheiss@hotmail.com


Education and Training:

  • 02/2012-04/2016: Dissertation passed with distinction. Development of genetic tools for recombinant protein expression in Lactobacillus plantarum.
  • 04/2011-10/2011: Project work at the University of Natural Resources and Life Sciences; group: Dr. Diethard Mattanovich; Cell engineering of protein producing yeast Pichia pastoris
  • 09/2009-12/2010: Diploma thesis at the University of Natural Resources and Life Sciences;  group: Dr. Diethard Mattanovich; Establishment and characterization of a novel secretion system in the methylotrophic yeast Pichia pastoris
  • 03-05/2009: University of Vienna; Institute of Microbiology and Genetics;                               group: Dr. Angela Witte; Identification and application of pha- genes in Haloarcula hispanica and H. marismortui
  • 07-09/2008: University of Münster; Institute of Molecular Microbiology and Biotechnology; group: Dr. Alexander Steinbüchel; Proteome analysis of Ralstonia eutropha H16 and R. eutropha G+1, its glucose utilizing mutant strain
  • 04-06/2008: Medical University Innsbruck; Division of Hygiene and Medical Microbiology group: Dr. Cornelia Speth; Examining the pathogenity of exogene proteases of Pseudallescheria and Scedosporium in human liquor
  • 10/2011-02/2012: University of Vienna; Biology
  • 10/2004-04/2011: University of Vienna; Molecular Biology

Internships:

  • 02/2007          Boehringer Ingelheim- Austria; marketing department
  • 07-09/2006    Laboratories Mühl-Speiser; medical-diagnostic service
  • 07-09/2005    Boehringer Ingelheim-Austria; quality assurance

Poster, Papers, Short Talk:

  • Evaluation of novel inducible promoter/repressor systems for recombinant protein expression in Lactobacillus plantarum. Heiss S, Hörmann A, Tauer C, Sonnleitner M, Egger E, Grabherr R and Heinl S. Microb Cell Fact. 2016. 15:50
  • Characterization of the Lactobacillus plantarum plasmid pCD033 and generation of the plasmid free strain L. plantarum 3NSH. Heiss S, Grabherr R, Heinl S. Plasmid 81. 2015. 9–20
  • Tuning constitutive recombinant gene expression in Lactobacillus plantarum. Tauer C, Heinl S, Egger E, Heiss S and Grabherr R. Microbial Cell Factories 2014, 13:150
  • Multistep processing of the secretion leader of the extracellular protein Epx1 in Pichia pastoris and implications on protein localization; Heiss S, Puxbaum V, Gruber C, Altmann F, Mattanovich D, Gasser B. Microbiology. 2015 Jul; 161(7):1356-68.
  • Proteomic and transcriptomic elucidation of the spontaneous mutant Ralstonia eutropha G+1 with regard to glucose utilization; Raberg M, Peplinski K, Heiss S, Ehrenreich A, Voigt B, Döring C, Bömeke M, Hecker M, Steinbüchel A; Appl Environ Microbiol. 2011 Mar; 77(6):2058-70.
  • Phylogeny and immune evasion: a putative correlation for cerebral Pseudallescheria/Scedosporium infections; Rainer J, Rambach G, Kaltseis J, Hagleitner M, Heiss S, Speth C. Mycoses. 2011 Oct;54 Suppl 3:48-55.
  • Identification and deletion of the major secreted protein of Pichia pastoris; Heiss S, Maurer M, Hahn R, Mattanovich D, Gasser B; Appl Microbiol Biotechnol. 2012 Jul 17

 

  • Poster and Short Talk at 25th International Congress on Yeast Genetics and Molecular Biology; July 11-16th, 2011; Olsztyn, Poland; Identification and characterization of the secretory  cysteine-rich protein family member Epx1 in Pichia pastoris; Heiss S, Dragosits M, Marx H, Maurer M, Puxbaum V, Mattanovich D, Gasser B
  • European Patent, 12190361.1-2401; Secretionssignal für Hefe (Expression Sequences); Date of filing: 29.10.12; Gasser B., Heiss S., Mattanovich D.
  •  Poster at at ECB15 (European Congress on Biotechnology); 24.-26. September, 2012; Istanbul; Improvement of Lactobacillus plantarum CD033 for biotechnological application; Heiss S, Spath K, Heinl S, Grabherr R; http://dx.doi.org/10.1016/j.nbt.2012.08.598
  • Complete DNA sequence and analysis pCD033, a plasmid derived from a Lactobacillus plantarum silage strain; Heinl S, Spath K, Heiss S, Grabherr R; http://dx.doi.org/10.1016/j.nbt.2012.08.600

Professional Affiliations:

  • ÖGMBT